A genetic screen for modifiers of Delta 1 dependent Notch signaling function in the mouse
نویسندگان
چکیده
Institute of Experimental Genetics, GSF Research Center for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany, Institute for Medical Microbiology, Immunology and Hygiene, Technical University Munich, Trogerstr. 30, 81675 Munich, Germany, Institute of Molecular Animal Breeding, Gene Center, University of Munich, Feodor-Lynen-Strasse 25, 81377 Munich, Germany, Institute of Biomathematics and Biometry, GSF Research Center for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
منابع مشابه
A screen for modifiers of notch signaling uncovers Amun, a protein with a critical role in sensory organ development.
Notch signaling is an evolutionarily conserved pathway essential for many cell fate specification events during metazoan development. We conducted a large-scale transposon-based screen in the developing Drosophila eye to identify genes involved in Notch signaling. We screened 10,447 transposon lines from the Exelixis collection for modifiers of cell fate alterations caused by overexpression of ...
متن کاملA genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse.
The Notch signaling pathway is an evolutionarily conserved transduction pathway involved in embryonic patterning and regulation of cell fates during development. Recent studies have demonstrated that this pathway is integral to a complex system of interactions, which are also involved in distinct human diseases. Delta1 is one of the known ligands of the Notch receptors. Mice homozygous for a lo...
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The Notch receptor is the central element in a cell signaling mechanism controlling a broad spectrum of cell fate choices. Genetic modifier screens in Drosophila and subsequent molecular studies have identified several Notch pathway components, but the biochemical nature of signaling is still elusive. Here, we report the results of a genetic modifier screen of the bristle phenotype of a gain-of...
متن کاملNotchless encodes a novel WD40-repeat-containing protein that modulates Notch signaling activity.
Signaling by Notch family receptors is involved in many cell-fate decisions during development. Several modifiers of Notch activity have been identified, suggesting that regulation of Notch signaling is complex. In a genetic screen for modifiers of Notch activity, we identified a gene encoding a novel WD40-repeat protein. The gene is called Notchless, because loss-of-function mutant alleles dom...
متن کاملThe Delta intracellular domain mediates TGF-β/Activin signaling through binding to Smads and has an important bi-directional function in the Notch–Delta signaling pathway
Delta is a major transmembrane ligand for Notch receptor that mediates numerous cell fate decisions. The Notch signaling pathway has long been thought to be mono-directional, because ligands for Notch were generally believed to be unable to transmit signals into the cells expressing them. However, we showed here that Notch also supplies signals to neighboring mouse neural stem cells (NSCs). To ...
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